Endocrine Abstracts

Case history: A 39 year old male patient presented via ambulance to our unit with a deliberate mixed overdose. He had a past medical history of type 2 diabetes mellitus, depression and hypertension. He had ingested an uknown amount of atenolol, dapagliflozin, ramipril, co-codamol with both cocaine and benzodiazepines detected in urine toxicology. On arrival to hospital, the patient had fluid refractory hypotension, with a systolic blood pressure of 70mmHg and HR 45BPM. Given t...

: A 78-year-old male with a background of renal cell carcinoma and bilateral adrenal metastasis presented with leg cramps and lethargy. He was on Prednisolone 10 mg od for immune therapy induced pneumonitis. Prior to commencing Prednisolone, he was on Dexamethasone 2 mg for 4 months for weight loss, nausea and vomiting. He underwent a Short Synacthen Test (SST) as his serum Na was low at 119 mmol/L (134–146). His SST showed a flat response with baseline and 30 minutes cor...

Cardiovascular diseases are the greatest cause of death globally. Obesity significantly increases the risk for the development of cardiovascular diseases. However research does not under stand the physiological and molecular connections of these diseases. We have identified that the hormone leptin in obesity plays a key role in elevating blood pressure in obesity. However recent findings in humans treated with leptin in the disease state of lipodystrophy, did not result in the...

Introduction: Graves’ disease is the commonest cause of thyrotoxicosis. If left untreated myriad of complications, chief among which are cardiac related morbidity and mortality might supervene.Case presentation: A 31-year-old man presented to the endocrine clinic of LAUTECH Teaching Hospital, Ogbomoso, Nigeria 19 months ago with features suggestive of hyperthyroidism and a diagnosis of thyrotoxicosis secondary to Graves’ disease was made. He wa...

Background: Pediatric patients with diabetes are required to adhere to strict regimens including blood glucose testing, insulin therapy, and dietary restrictions. Adequate glucose control is necessary to prevent acute and chronic complications. Testing Hemoglobin A1c (HgbA1c) provides a simple evaluation of diabetes control and compliance with therapy. Psychological factors (depression, anxiety) play a major role in pediatric diabetes compliance. Access to psychological suppor...

Insulin resistance and androgen excess, alongside anovulatory infertility, are the cardinal clinical and biochemical features of polycystic ovary syndrome (PCOS). Circulating androgen burden and metabolic dysfunction in PCOS are closely correlated, but an independent contribution of androgens per se to metabolic and other complications of PCOS remains poorly characterised. My work since 2012 has focused on delineating the distinct impact of androgens on metab...

We audited 46 pituitary MRI scans for patients with hypogonadotropic hypogonadism. We were particularly interested to see if adopting The Endocrine Society’s (TES) 2010 guidelines for Testosterone Therapy in Men with Androgen Deficiency Syndromes (pituitary MRIs only for those with testosterone level below 5.3 mmol/l, panhypopituitarism, persistent hyperprolactinaemia or if the patient has symptoms consistent with a mass effect such as headaches, a visual field defect or ...

Patients with Familial Hypercholesterolaemia (FH) have premature Cardiovascular disease and have a standardised mortality ratio nine times greater than normal. FH must therefore be correctly diagnosed and treated aggressively. Referral for FH is based on fulfilling the Simon Broome’s (SB) Criteria. We aimed to evaluate practice at Queen Alexandra Hospital with regards to referral for FH genetic mutation. We set out to see whether SB’s criteria were being fulfilled wh...

Introduction: Pituitary adenomas are not uncommon presentations in our clinical practice but the challenge with management becomes more daunting as the size of the tumour gets bigger as seen in this woman we present herein with a macroadenoma. The combination of factors militating against accessing the best of health care available is unconnected with the usual problems affecting health care delivery in Sub-Saharan Africa, including out-of-pocket payments for health services a...

Background: Obesity is significant risk factor for cardiovascular diseases and type 2 diabetes mellitus. Many anthropometric indexes are now being used in clinical practice to identify and determine the prevalence of obesity.Aim: This study determined the relationship between common anthropometric indexes and percentage body fat (%BF).Methodology: Ninety-four volunteer subjects participated in this cross sectional hospital based st...